rude slang Life is characterized by struggle, suffering, or misfortune (and before you know it, you're on your deathbed). A generic lamentation usually said following some tragedy or bad luck. So you lost your job, and then you found out your boss was sleeping with your husband? Wow, life's a bitch. After finally getting out of debt, Sean was diagnosed with cancer and has been bedridden for months. I tell you, life is a bitch, and then you die.